Margot Robbie, Idris Elba, John Cena, Daniela Melchior, Joel Kinnaman, Sylvester Stallone, David Dastmalchian, Viola Davis, Joaquín Cosío, Peter Capaldi, Michael Rooker, Jai Courtney, Alice Braga, Pete Davidson, Juan Diego Botto, Storm Reid, Nathan Fillion, Taika Waititi, Steve Agee, Sean Gunn, Flula Borg, Mayling Ng, Jennifer Holland, Tinashe Kajese, Lynne Ashe, Julio Ruiz, Dee Bradley Baker, John Ostrander, Stephen Blackehart, Angel Airan Bonilla, Natalia Safran, Pom Klementieff, Lloyd Kaufman, Andrew Ayala, James William Ballard, Timothy Carr, Diezel Ramos, Jared Leland Gore, Mikaela Hoover, Gerardo Davila, Josh Ventura, Giovannie Cruz, Sergio Carlo, Edgar Zanabria
Supervillains Harley Quinn, Bloodsport, Peacemaker and a collection of nutty cons at Belle Reve prison join the super-secret, super-shady Task Force X as they are dropped off at the remote, enemy-infused island of Corto Maltese.